Chordoma

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Chordoma

PURPOSES To review in the literature, all the epidemiological, clinical, radiological, histological and therapeutic data regarding chordomas as well as various notochordal entities: ecchordosis physaliphora, intradural and intraparenchymatous chordomas, benign notochordal cell tumors, parachordomas and extra-axial chordomas. To identify different types of chordomas, including familial forms, as...

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Thoracic chordoma.

Dra. Rita Delgado – Rua Borges Lagoa 1080 / 307 04038-002 São Paulo SP Brasil. E-mail: [email protected] Chordomas are slow-growing tumors with aggressive local behavior that probably originate from embryonic remnants of the notochord. This is a midline structure along the neural tube that presents involution and fragmentation as ossification of the axial skeleton occurs, in such way that i...

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Thoracic chordoma.

Remnants of the notochord sometimes become activated into tumour formation; Ribbert (1895) established the origin of such tumours, and called them chordomata. They can arise at any point along the length of the original notochord, and Coenen (1925) first classified them according to their site of origin into cranial, vertebral, and caudal or sacro-coccygeal. Mabrey (1935) in a comprehensive rev...

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Intradural metastases of chordoma.

A 59-year-old man with sacral chordoma had several resections of locally recurring disease during a 6-year period following diagnosis. The present hospital admission of the patient, now 65, was prompted by several weeks of pain in the right buttock and progressive difficulty in walking. A tender soft-tissue mass in the right buttock area, weakness and muscle atrophy of both lower extremities, a...

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Molecular profiling of chordoma

The molecular basis of chordoma is still poorly understood, particularly with respect to differentially expressed genes involved in the primary origin of chordoma. In this study, therefore, we compared the transcriptional expression profile of one sacral chordoma recurrence, two chordoma cell lines (U-CH1 and U-CH2) and one chondrosarcoma cell line (U-CS2) with vertebral disc using a high-densi...

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ژورنال

عنوان ژورنال: Cancer

سال: 2001

ISSN: 0008-543X

DOI: 10.1002/1097-0142(20010225)93:1<40::aid-cncr9006>3.0.co;2-d